品牌 | SOLARBIO/索萊寶 | 貨號 | K106624P |
---|---|---|---|
規(guī)格 | 50ul/100ul | 供貨周期 | 現(xiàn)貨 |
主要用途 | IHC | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)林牧漁 |
Anti-BAX Polyclonal Antibody
英文名稱 | Anti-BAX Polyclonal Antibody |
---|---|
宿主 | Rabbit |
別名 | Bcl2-L-4;Bax-protein;BAX_HUMAN;BAXA |
應(yīng)用 | IHC |
稀釋比例 | IHC 1:50-200. |
交叉反應(yīng) | Human |
蛋白分子量 | 21kDa |
Gene ID | 581 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
儲(chǔ)存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
純化方法 | Affinity purification |
亞型 | IgG |
免疫原 | A synthetic peptide of human BAX |
性狀 | 液體 |
Public Immunogen Range | A synthetic peptide of human BAX |
Subcellular Locations | Cytoplasm Cell membrane |
Swiss Prot | Q07812 |
克隆類型 | Polyclonal Antibody |
背景資料 | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7 |